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. 2019 Sep 23;12:7809–7821. doi: 10.2147/OTT.S212596

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© 2019 Zhou et al.

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The effects of a combination of SB431542 and RFA on the EMT in subcutaneous tumor cells. A patient-derived BC cell line (patient no. 1) was injected into nude mice to form subcutaneous tumors. RFA of the tumor tissues was performed, and the mice were treated with SB431542 at a dose of 1 mg/kg via oral administration. Tumors were then harvested for qPCR experiments. The mRNA levels of E-cadherin (A), N-cadherin (B), vimentin (C), ZEB1 (D), twist (E) and Snail (F) in tumor tissues are shown as scatter diagrams. *P<0.05.

Abbreviations: BC, bladder cancer; RFA, radiofrequency ablation; EMT, epithelial–mesenchymal transition; ZEB1, zinc finger E-box binding homeobox 1.