Table 3.
Relationship between clinical risk factors and global network properties in the preterm cohort.
| Risk Factors Studied | Preterm infants (n=66) | Global network metric | Model p-value | Association with global network metrics |
|---|---|---|---|---|
| Mild brain injury | 21 (32%) | cc | 0.002 | β=0.001; p=0.94 |
| L | 0.002 | β=0.01; p=0.85 | ||
| gE | 0.011 | β=−0.001; p=0.86 | ||
| lE | 0.0008 | β=0.002; p=0.85 | ||
| Moderate to severe bronchopulmonary dysplasia* | 24 (37%) | cc | 0.0005 | β=−0.02 ;p=0.15 |
| L | <0.0001 | β=+0.17; p=0.01* | ||
| gE | <0.0001 | β=−0.03; p= 0.02* | ||
| lE | 0.0001 | β=−0.02; p=0.05 | ||
| Length of oxygen support (days) | 67 ± 41 [0-172] | cc | 0.0006 | β=−0.0004 ; p=0.36 |
| L | 0.0001 | L: β=+0.0027; p=0.03* | ||
| gE | 0.0001 | gE: β=−0.004; p=0.01* | ||
| lE | <0.0001 | lE: β =−0.0004; p=0.026* | ||
| Postnatal steroid treatment | 21 (32%) | cc | 0.0013 | β=−0.001; p=0.92 |
| L | 0.0012 | β=−0.038; p=0.58 | ||
| gE | 0.0006 | β=2.2×10”6; p=0.99 | ||
| lE | 0.0006 | β=0.005; p=0.69 | ||
| Necrotizing enterocolitis | 19 (29%) | cc | 0.0019 | β=−0.004; p=0.78 |
| L | 0.0017 | β=−0.05; p=0.42 | ||
| gE | 0.0011 | β=0.002; p=0.84 | ||
| lE | 0.0007 | β=0.006; p=0.63 | ||
| Cardiac vasopressor treatment | 19 (30%) | cc | 0.0006 | β=0.021; p=0.18 |
| L | 0.0014 | β=−0.02; p=0.76 | ||
| gE | 0.0006 | β=−9.9 ×10−6; p=0.99 | ||
| lE | 0.0003 | β=0.016; p=0.18 | ||
| Surgical ligation of patent ductus arteriosus | 12 (18%) | cc | 0.002 | β=0.0018; p=0.92 |
| L | 0.0023 | β=3.6χ10−4 ; p=0.99 | ||
| gE | 0.0011 | β=−0.002 ; p=0.86 | ||
| lE | 0.0008 | β=7χ10−4 ; p=0.96 |
*
Severity of BPD in VPT infants: treatment with oxygen for at least 28 days and need for more than 21% oxygen support (moderate: less than 30% oxygen; severe: more than 30% oxygen) at discharge or at 36 weeks postmenstrual age (PMA) whichever comes first [30]