Table 2.
MNI Coordinates of RSFC Seeds and Between-group Differences in Connectivity: Follow-up Analyses in Children with Useable Task And Resting State Data.
| Seed | Direction | Seed x,y,z | Target | Target x,y,z | Cluster Size | b |
|---|---|---|---|---|---|---|
| Cingulo-opercular | ||||||
| L ant AI/FO | RD>TD | −51, 13, 18 | PostCG/ R SPL | 48,−32,60 | 238 | 0.210 |
| L med AI/FO | RD>TD | −33, 24, 1 | R SPL | 12,−56, 68 | 618 | 0.201 |
| L lat AI/FO | RD>TD | −34, 14, 5 | L Cerebellum | −4, −76, −26 | 523 | 0.227 |
| L aPFC | −28, 51, 15 | - | ||||
| L ant Thalamus | −12, −15, 8 | - | ||||
| R ant AI/FO | RD>TD | 36, 16, 4 | R SPL | 38,−52,70 | 212 | 0.277 |
| R med AI/FO | RD>TD | 33, 25, −1 | - | |||
| R lat AI/FO | RD>TD | 45, 23, −4 | Cerebellum | 0,−74,−22 | 1302 | 0.264 |
| RD>TD | L Cerebellum | −24,−58,−42 | 272 | 0.209 | ||
| RD>TD | L Cerebellum/FFG | −26,−64,−22 | 239 | 0.248 | ||
| TD>RD | L MTG | −52,−38,−8 | 556 | −0.292 | ||
| TD>RD | L AG | −62,−64,24 | 169 | −0.281 | ||
| TD>RD | L SFG | −4,30,58 | 162 | −0.281 | ||
| TD>RD | R IFG | 52,24,18 | 141 | −0.359 | ||
| R ant PFC | TD>RD | 27, 50, 23 | R PreCG/IFG | 48,0,28 | 613 | −0.282 |
| R ant Thalamus | 10, −15, 8 | - | ||||
| Dorsal ACC | TD>RD | −1, 10, 46 | L AG | −64,−58,28 | 259 | −0.279 |
| TD>RD | L SFG | −22,22,32 | 171 | −0.305 | ||
| Frontoparietal | ||||||
| L DLPFC | RD>TD | −43, 22, 34 | R SMG/PostCG | 48,−34,56 | 282 | 0.305 |
| RD>TD | L SMG | −58,−36,52 | 245 | 0.287 | ||
| Midcingulate | RD>TD | 0, −29, 30 | L ITG | −40,−48,−8 | 237 | 0.232 |
| L IPL * | TD>RD | −51, −51, 36 | R SFG | 28,−2,64 | 378 | −0.272 |
| TD>RD | L CentOpercular | −48,4,2 | 233 | −0.193 | ||
| TD>RD | ACC | 0,26,30 | 175 | −0.195 | ||
| L IPS ** | TD>RD | −31, −59, 42 | PCC | −4,−46,12 | 348 | −0.212 |
| L Precuneus | −9, −72, 37 | - | ||||
| R DLPFC | 43, 22, 34 | - | ||||
| R IPL | 51, 47, 42 | - | ||||
| R IPS | 30, −61, 39 | - | ||||
| R Precuneus | 10, −69, 39 | - |
indicates significant association with Simon task performance
significant association with reading accuracy. Direction indicates whether connectivity is greater in RD or TD groups; Seed x,y,z, provides the MNI coordinate for the center of each seed; Target identifies the location of the target cluster showing significant group differences in connectivity with the seed (all passing voxel-wise p<.001, FDR cluster size correction q<.05); Target x,y,z provides the MNI coordinate for the peak of each target cluster; Cluster size provides the number of significant voxels in the target cluster; b provides the unstandardized coefficient for group differences from regression analysis on average cluster connectivity, controlling for ADHD symptoms, age, FSIQ, and mean motion (all passing Bonferroni correction p<.0025). ACC, anterior cingulate cortex; AG, angular gyrus; AI/FO, anterior insula-frontal operculum; aPFC, anterior prefrontal cortex; CentOpercular, central operculum; DLPFC, dorsolateral prefrontal cortex; IFG, inferior frontal gyrus; IPL, inferior parietal lobule; IPS intraparietal sulcus; L, left; MTG, middle temporal gyrus, PCC, posterior cingulate; PreCG, precentral gyrus, PostCG, postcentral gyrus; SFG, superior frontal gyrus; SMG, supramarginal gyrus; SPL, superior parietal lobule.