4.

血浆RAS突变状态与患者临床特征关系

Clinical features and RAS mutations in plasma (n=71)

Clinical feature	n	RAS mutation		P
		The number of mutation	Mutation rate (%)
#The 71 patients, included 1 patient in stage Ⅱ, 1 patient in stage Ⅲ, 34 patients in stage Ⅳa, and 35 patients in stage Ⅳb. Stage Ⅱ and Ⅲ were not analyzed because of the small sample size.
Age of blood collection (year)				0.072
< 65	40	9	22.50
≥65	31	14	45.16
Gender				0.320
Male	40	15	37.50
Female	31	8	25.81
Locus tumor site				0.324
Left hemicolon	27	9	33.33
Right hemicolon	21	9	42.86
Rectum	23	5	21.74
Stage#				0.450
Ⅳa	34	13	38.24
Ⅳb	35	10	28.57
Liver metastasis				0.045
Yes	40	17	42.50
No	31	6	19.35
Lung metastasis
Yes	21	5	23.81	0.237
No	50	18	36.00
CEA				0.284
Normal	26	10	38.46
High	45	13	28.89
CA199				0.427
Normal	48	14	29.17
High	23	9	39.13