. 2019 Jul 20;39(7):823–829. [Article in Chinese] doi: 10.12122/j.issn.1673-4254.2019.07.12

1.

AT-1及其衍生肽的特性和抗菌活性

Physicochemical parameters and antimicrobial activities ofAT-1 and its derivatives

Peptides	Sequence	Theoretical MW	Measured MW^a	Net charge	H^b	S.mutans ATCC25175
Peptides	Sequence	Theoretical MW	Measured MW^a	Net charge	H^b	MIC (µg/mL)	MBC (µg/mL)
^aMolecular weight (MW) was measured by mass spectroscopy; ^bThe hydrophobicity (H) were estimated through heliquest website; Replaced amino acids are indicated by bold letters.
AT-1	ATGTARKLLDAMA	1317.55	1317.58	+1	0.28	>200	>200
AT-2	LRRWLRKLLRRMR	1742.21	1742.23	+7	0.25	25	50
AT-3	LRRWLRKLLRWMR	1882.38	1882.42	+6	0.50	6.25	12.5-25
AT-4	LWRWLRKLLRRMR	1882.38	1882.42	+6	0.50	12.5	25
AT-5	LTRTLWKLLRRMR	1910.40	1910.43	+5	0.44	50	50
AT-6	LRRWLRWLLRRMR	1723.20	1742.23	+6	0.50	12.5	12.5-25
AT-7	LRRWLWKLLWRMR	1912.41	1912.45	+5	0.75	6.25	12.5