3.
结核病例组与对照组的HLA-DRB1等位基因频率比较
Frequencies of HLA-DRB1 alleles in active tuberculosis group and control group
| HLA-DRB1 | APTB (n=294) | Control (n=453) | χ2 | OR (95% CI) | P | Pc | |||
| Positive (n) | GF (%) | Positive (n) | GF (%) | ||||||
| GF: Gene frequency; OR: Odds ratio; CI: Confidence interval; Pc: P value after Bonferroni correction. | |||||||||
| 1202 | 61 | 10.4 | 146 | 16.1 | 9.845 | 0.603(0.438-0.829) | 0.002 | 0.044 | |
| 0901 | 97 | 16.5 | 133 | 14.7 | 0.801 | 1.1390(0.856-1.515) | 0.371 | 8.162 | |
| 1501 | 60 | 10.2 | 89 | 9.9 | 0.058 | 1.0430(0.737-1.473) | 0.810 | 17.820 | |
| 1101 | 30 | 5.1 | 56 | 6.2 | 0.765 | 0.816(0.517-1.288) | 0.382 | 8.404 | |
| 1201 | 14 | 2.4 | 50 | 5.5 | 8.562 | 0.418(0.229-0.763) | 0.003 | 0.066 | |
| 0301 | 36 | 6.1 | 49 | 5.4 | 0.339 | 1.141(0.732-1.777) | 0.561 | 12.342 | |
| 0405 | 24 | 4.1 | 43 | 4.8 | 5.577 | 0.543(0.325-0.908) | 0.018 | 0.396 | |
| 1502 | 24 | 4.1 | 41 | 4.5 | 0.169 | 0.898(0.537y-1.502) | 0.681 | 14.982 | |
| 0803 | 44 | 7.5 | 37 | 4.1 | 8.035 | 1.900(1.211-2.980) | 0.005 | 0.110 | |
| 1602 | 34 | 5.8 | 35 | 3.9 | 2.981 | 1.527(0.941-2.478) | 0.084 | 1.848 | |
| 0701 | 22 | 3.7 | 34 | 3.8 | 0.000 | 0.997(0.577-1.722) | 0.991 | 21.802 | |
| 1401 | 0 | 0.0 | 28 | 3.1 | 18.520 | — | < 0.0001 | 0.000 | |
| 0403 | 20 | 3.4 | 25 | 2.8 | 0.503 | 1.241(0.683-2.255) | 0.478 | 10.516 | |
| 1302 | 7 | 1.2 | 22 | 2.4 | 2.870 | 0.484(0.205-1.141) | 0.090 | 1.980 | |
| 0406 | 11 | 1.9 | 18 | 2.0 | 0.025 | 0.941(0.441-2.006) | 0.874 | 19.228 | |
| 1001 | 11 | 1.9 | 15 | 1.6 | 0.097 | 1.132(0.516-2.483) | 0.756 | 16.632 | |
| 1405 | 13 | 2.2 | 13 | 1.5 | 1.256 | 1.553(0.715-3.375) | 0.263 | 5.786 | |
| 1404 | 1 | 0.2 | 12 | 1.3 | 5.509 | 0.127(0.016-0.979) | 0.019 | 0.418 | |
| 1312 | 10 | 1.7 | 4 | 0.5 | 6.090 | 3.901(1.22-12.50) | 0.014 | 0.308 | |
| 0404 | 8 | 1.4 | 3 | 0.3 | 5.170 | 4.152(1.097-15.72) | 0.023 | 0.506 | |
| 1454 | 44 | 7.5 | 0 | 0.0 | 69.850 | — | < 0.0001 | 0.000 | |
| others | 17 | 2.9 | 51 | 5.6 | 6.153 | 0.499(0.285-0.873) | 0.013 | 0.286 | |