. 2018 Apr 20;38(4):460–465. [Article in Chinese] doi: 10.3969/j.issn.1673-4254.2018.04.15

3.

比较两组大鼠在不同时间点血清胰岛素的量和海马IRS1、IRS2的m-RNA表达量

Serum insulin level and expression levels IRS1 and IRS2 mRNAs in the hippocampus of rats in the two groups at different time points (Mean±SD)

Group	4th week	8th week	12th week	16th week	20th week
The serum insulin concentrations vs CD group, ^μP＜0.01; m-RNA expression levels IRS1 in the hippocampus vs CD group, ^*P＜0.05; m-RNA expression levels IRS2 in the hippocampus vs CD group, ^#P＜0.05.
HFD insulin	9.00±1.45^μ	15.37±2.81^μ	14.33±1.89^μ	18.79±0.93^μ	28.49±2.73^μ
IRS1		1.013±0.185^*	0.850±0.076^*	0.545±0.091^*	0.308±0.120^*
IRS2		0.245±0.112^#	0.308±0.130^#	0.425±0.117^#	0.458±0.161^#
CD insulin	9.52±1.77	11.43±1.72	11.68±1.948	12.66±1.77	20.07±1.62
IRS1		1.085±0.112	1.10±0.088	0.943±0.071	0.860±0.123
IRS2		0.945±0.081	0.972±0.193	1.205±0.241	1.282±0.236