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. 2019 Mar 20;39(3):298–303. [Article in Chinese] doi: 10.12122/j.issn.1673-4254.2019.03.07

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地尔硫卓对肝癌MHCC97H, 7402细胞MTDH mRNA表达的影响

Effect of diltiazem on expression of MTDH mRNA in MHCC97H and 7402 cells (n=3, Mean±SD)

Cell lines	Diltiazem (μmol/L)	MTDH-mRNA
Cell lines	Diltiazem (μmol/L)	12 h	24 h	48 h
^P < 0.05, ^*P < 0.01 vs control.
MHCC97H	0 (control)	1.000±0.000	1.000±0.000	1.000±0.000
	25	0.737±0.262^**	0.407±0.021	0.049±0.015^*
	50	1.670±0.670^**	5.740±0.337^**	0.069±0.031
	100	0.182±0.818^**	0.050±0.013^**	0.028±0.010^*
	200	0.008±0.992^**	1.349±0.290	0.256±0.180
	400	0.017±0.983^**	3.647±0.290^*	0.348±0.112^**
7402	0 (control)	1.000±0.000	1.000±0.000	1.000±0.000
	25	2.782±0.151^**	3.135±0.114^**	8.868±0.691^**
	50	0.094±0.002^**	2.526±0.121^**	0.645±0.164
	100	0.125±0.025^**	5.017±0.187^**	3.709±0.589^**
	200	0.099±0.002^**	2.626±0.112^**	1.370±0.216
	400	0.681±0.150^**	3.808±0.200^**	2.427±0.655^*