1.
各组大鼠HR、MAP、RPP的变化
Hemodynamic parameters of the isolated rat heart (Mean±SD, n=6/group)
| Group | Baseline | Ischemia 30 min | Reperfusion (min) | ||
| 30 | 60 | 120 | |||
| IR group: Ischemia reperfusion group; PD group: Treatment with PD98059; EM50 group, EM50 + PD group: Endomophin-1 post-treatment group with or without PD98059; &P < 0.05 vs S group; *P < 0.05 vs IR group; #P < 0.05 vs EM50 group. | |||||
| HR (beats/min) | |||||
| Sham | 391.18±10.32 | 382.58±10.52 | 386.39±10.67 | 383.27±7.26 | 377.26±8.38 |
| IR | 381.48±15.51 | 287.19±9.74 & | 297.75±16.72 & | 279.48±5.78 & # | 275.23±9.25 & # |
| EM50 | 393.94±7.62 | 339.14±19.06 & * | 343.35±13.92 & * | 332.44±2.81 & * | 323.51±18.14 & * |
| EM50+PD | 398.36±18.21 | 295.22±22.56 & # | 293.97±3.92 & # | 293.09±29.21 & # | 288.23±22.92 & # |
| PD | 390.20±21.29 | 319.37±33.44 & | 322.65±35.77 & | 296.77±34.69 & | 268.92±26.08 & # |
| MAP (mmHg) | |||||
| Sham | 115.62±8.67 | 90.49±0.90 | 93.50±4.32 | 83.88±4.23 | 77.90±1.41 |
| IR | 110.63±3.91 | 77.88±1.91 & # | 73.05±9.82 & # | 62.21±1.31 & # | 52.06±9.20 & # |
| EM50 | 107.57±3.69 | 85.75±4.38* | 87.35±3.72* | 78.26±2.22* | 73.86±4.17* |
| EM50+PD | 112.26±7.57 | 70.48±2.33 & *# | 75.45±4.83 & # | 66.64±5.48 & # | 64.03±1.03 & # |
| PD | 103.64±4.71 | 80.55±2.27 & # | 76.16±5.90 & # | 60.35±2.28 & # | 61.57±3.11 & # |
| RPP (mmHg/min/10-3) | |||||
| Sham | 45.20±2.88 | 34.63±1.29 | 36.10±0.68 | 32.16±2.00 | 29.38±0.36 |
| IR | 42.19±1.93 | 22.37±1.09 & | 21.67±2.22 & | 17.38±0.28 & | 14.28±2.13 & |
| EM50 | 42.38±1.93 | 29.10±2.44* | 29.99±1.99* | 26.01±0.52* | 23.86±0.97* |
| EM50+PD | 44.81±5.00 | 20.77±0.92 & # | 22.17±1.16 & # | 19.64±3.46 & # | 18.45±1.37 & # |
| PD | 40.39±1.54 | 25.70±2.38 & | 24.44±0.86 & | 17.92±2.37 & | 16.52±1.23 & |