Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Possible mechanisms contributing to the inhibition of fat synthesis and glucose utilization of M. charantia. M. charantia stimulates glucose transporter 4 (GluT-4) to migrate to the cell membrane and mediate glucose uptake by increasing adiponectin, and the adenosine monophosphate-activated protein kinase (AMPK) activity. In addition, M. charantia blocks the expression of PPARγ, and PPARγ downstream pathway including C/EBPα and PI3K to reduce the accumulation of fat.
