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Spherical Nucleic Acids.131 A. SNAs present nucleic acids in an outward facing spherical array. B. Oligonucleotide-tocopherol conjugates form SNAs with liposomal cores. C. Structure of linkage and tocopherol moiety. D. TLR agonizing oligonucleotides conjugated to tocopherol can be combined with antigens through a complementary oligonucleotide and chemical conjugation through a linker. E. Different conjugate linkage chemistries explored.
