Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Timeline for Key Advances in Therapeutic Oligonucleotides. The various substitutions and the advances of chemical modifications are shown in yellow, main discoveries and technological achievements are noted in blue, and clinical studies are highlighted in green. Adapted from Lundin, K. E., Gissberg, O., and Smith, C. I. E. (2015) Oligonucleotide Therapies: The Past and the Present. Hum. Gene Ther. 26, 475–485.159 Copyright 2015, Mary Ann Liebert, Inc.
