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Strategies for the delivery of ASO and/or siRNA.57 A: Covalent conjugation between the agent and the oligonucleotide. B: Examples of stable and cleavable linkages. C: Formation of a complex between a biomolecule or a polymer and the oligonucleotide via electrostatic interactions and/or the hydrophobic effect. D: Formation of liposomal supramolecular structure with targeting or transfecting agent (PEG, peptide, CPP, protein, lipid glycoconjugate, etc.).
