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. Author manuscript; available in PMC: 2019 Sep 29.
Published in final edited form as: Bioconjug Chem. 2019 Jan 29;30(2):366–383. doi: 10.1021/acs.bioconjchem.8b00761

Figure 6.

Figure 6.

CPP grafting strategy on siRNA. A: Noncleavable oligonucleotide CPP conjugate. B: Representation of the cleavable conjugate by reduction of the disulfide bridge: (1) Bioconjugate enters into the cell thanks to CPP. (2) Cleavage of the disulfide bridge allows detachment of the siRNA from the CPP moiety. (3) CPP enters into the nucleus. (4) siRNA elicits its inhibitory activity by an RNAi mechanism. Adapted with permission from Ye, J., Liu, E., Gong, J., Wang, J., Huang, Y., He, H., and Yang, V. C. (2017) High-Yield Synthesis of Monomeric LMWP(CPP)-SiRNA Covalent Conjugate for Effective Cytosolic Delivery of SiRNA. Theranostics 7, 2495–2508.83 Copyright 2017, Ivyspring.