Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 15;2019:2828493. doi: 10.1155/2019/2828493

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Ying Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

A schematic model of 15s-HpETE on the redox regulation of the tumor suppressor PTEN by the Trx system and Prx. Trx and Prx III play vital roles in the control of endogenous lipid peroxide-induced redox regulation of PTEN. 15s-HpETE inhibits the Trx redox system by inducing dimerization of Trx, resulting in the delayed reduction of oxidized PTEN and oxidized Prx. Prx III prevents 15s-HpETE-mediated PTEN oxidation by catalyzing the reduction of lipid peroxide. TrxR: thioredoxin reductase; Trx: thioredoxin; Prx: peroxiredoxin.