Table 4.
Characteristics and occurrence of adverse maternal outcomes in women with early-onset and late-onset preeclampsia.
| EOP (n = 113) | LOP (n = 101) | Total (n = 214) | p | |
|---|---|---|---|---|
| Maternal age at EDD, years ± SD (range) | 30.7 ± 5.5 (19.00–48.00) | 30.1 ± 5.3 (19.00–47.00) | 30.43 ± 5.4 (19.00–48.00) | ns |
| Gestational age at inclusion, weeks ± SD (range) | 30.0 ± 2.5 (22.0–33.0) | 36.2 ± 1.4 (34.0–39.3) | 33.1 ± 1.6 (22.0–39.3) | 0.00001 |
| Systolic blood pressure on admission, mmHg ± SD (range) | 178 ± 18 (140–240) | 168 ± 18 (120–230) | 173 ± 18 (120–240) | 0.005 |
| Diastolic blood pressure on admission, mmHg ± SD (range) | 109 ± 12 (90–150) | 104 ± 11 (70–145) | 106 ± 11 (70–150) | 0.026 |
| Antihypertensive drug administration, n (%) | ||||
| Methyldopa | 106 (93.8) | 90 (90.0) | 196 (94.8) | ns |
| Calcium channel blocker | 46 (40.7) | 29 (29.0) | 75 (35.0) | ns |
| Beta-blocker | 65 (57.5) | 26 (26.0) | 91 (42.5) | <0.001 |
| Resistant hypertension, n (%) | 34 (30.0) | 2 (2.0) | 36 (16.8) | <0.0001 |
| MgSO4 administered, n (%) | 65 (57.5) | 30 (30.0) | 85 (45.8) | <0.001 |
| Admission-to-delivery interval, days ± SD (range) | 6.8 ± 6.8 (1–30) | 6 ± 8.5 (1–53) | 6 ± 7.0 (1–53) | 0.021 |
| Gestational age at delivery, weeks ± SD (range) | 30.6 ± 2.2 (23.0–33.8) | 36.6 ± 1.4 (34.0–39.5) | 33.9 ± 1.9 (23.0–39.5) | <0.0001 |
| Delivery-to-discharge interval, days ± SD (range) | 6.7 ± 3.5 (3–24) | 6.4 ± 3.6 (3–30) | 6.5 ± 3 (3–30) | ns |
| Severe preeclampsia, n (%) | 109 (96.4) | 87 (87.0) | 196 (91.5) | 0.0412 |
| HELLP, n (%) | 5 (4.4) | 4 (4.0) | 9 (4.2) | ns |
| Eclampsia before delivery, n (%) | 0 (0.0) | 2 (2.0) | 2 (0.9) | ns |
| Postpartum eclampsia, n (%) | 17 (15.0) | 7 (7.0) | 24 (11.2) | ns |
| Placental abruption, n (%) | 19 (16.8) | 4 (4.0) | 23 (10.7) | 0.004 |
| Hemorrhage, n (%) | 3 (2.6%) | 1 (1.0) | 4 (1.8) | ns |
| Blood transfusion, n (%) | 12 (10.6) | 7 (7.0) | 19 (8.8) | ns |
| Albumin transfusion, n (%) | 22 (19.4) | 8 (8.0) | 30 (14.0) | 0.019 |
| Anemia, n (%) | 50 (44.2) | 40 (40.0) | 90 (42.0) | ns |
| Pulmonary edema, n (%) | 5 (4.4) | 0 (0.0) | 5 (2.3) | ns |
| Hysterectomy, n (%) | 0 (0.0) | 1 (1.0) | 1 (0.4) | ns |
| Maternal death, n (%) | 1 (0.8) | 0 | 1 (0.4) | ns |
| DIC, n (%) | 0 (0.0) | 2 (2.0) | 2 (0.9) | ns |
| ICU, n (%) | 22 (19.4) | 6 (6.0) | 28 (13.0) | 0.02 |
| Uterine contraction disorders, n (%) | 3 (2.6) | 1 (1.0) | 4 (1.8) | ns |
| Thrombosis, n (%) | 2 (1.7) | 4 (4.0) | 6 (2.8) | ns |
| Healing disorders of the scar, n (%) | 3 (2.6) | 6 (6.0) | 9 (4.2) | ns |
| Genitourinary infection, n (%) | 31 (27.4) | 15 (15.0) | 46 (21.5) | 0.0385 |
DIC, disseminated intravascular coagulation; EDD, estimated date of delivery; EOP, early-onset preeclampsia; HELLP, hemolysis, elevated liver enzymes, low platelets; ICU, intensive care unit; LOP, late-onset preeclampsia; ns, nonstatistically significant; SD, standard deviation.