Table 5.
Diagnostic values of GP73, APRI, and FIB-4 for advanced fibrosis (F ≥ 3) and cirrhosis (F = 4).
| Parameters | AUC | 95% CI | Cutoff value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | P value |
|---|---|---|---|---|---|---|---|---|
| F ≥ 3 (Cohort A) | ||||||||
| GP73 | 0.761 | (0.678, 0.831) | 63.89 | 81.82 | 58.46 | 66.7 | 76.0 | <0.0001 |
| APRI | 0.796 | (0.717, 0.861) | 1.5 | 45.45 | 84.62 | 75.0 | 60.4 | <0.0001 |
| FIB-4 | 0.848 | (0.775, 0.905) | 3.25 | 59.09 | 87.69 | 83.0 | 67.9 | <0.0001 |
| F = 4 (Cohort A) | ||||||||
| GP73 | 0.779 | (0.698, 0.847) | 64.96 | 91.43 | 52.08 | 41.0 | 94.3 | <0.0001 |
| APRI | 0.836 | (0.761, 0.895) | 2.0 | 51.43 | 90.62 | 66.7 | 83.7 | <0.0001 |
| FIB-4 | 0.904 | (0.840, 0.948) | 3.25 | 85.71 | 84.37 | 66.7 | 94.2 | <0.0001 |
| F ≥ 3 (Cohort B) | ||||||||
| GP73 | 0.709 | (0.619, 0.788) | 93.74 | 71.43 | 55.66 | 17.5 | 93.7 | 0.0037 |
| APRI | 0.839 | (0.761, 0.900) | 1.5 | 57.14 | 95.24 | 61.5 | 94.3 | <0.0001 |
| FIB-4 | 0.829 | (0.749, 0.891) | 3.25 | 57.14 | 91.43 | 47.1 | 94.1 | <0.0001 |
GP73: Golgi protein 73; APRI: AST-to-platelet ratio index; FIB-4: fibrosis index based on four factors; AUC: area under the curve; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value.