Table 1.
Association between AURKA gene polymorphisms and Wilms tumor susceptibility.
| Genotype | Cases (N = 143) | Controls (N = 531) | P a | Crude OR (95% CI) | P | Adjusted OR (95% CI)b | P b |
|---|---|---|---|---|---|---|---|
| rs1047972 C>T (HWE = 0.598) | |||||||
| CC | 110 (76.92) | 412 (77.59) | 1.00 | 1.00 | |||
| CT | 30 (20.98) | 110 (20.72) | 0.89 (0.57–1.39) | 0.613 | 0.89 (0.57–1.39) | 0.622 | |
| TT | 3 (2.10) | 9 (1.69) | 1.09 (0.29–4.08) | 0.898 | 1.10 (0.29–4.10) | 0.891 | |
| Additive | 0.945 | 1.05 (0.71–1.55) | 0.809 | 1.04 (0.71–1.54) | 0.834 | ||
| Dominant | 33 (23.08) | 119 (22.41) | 0.866 | 1.04 (0.67–1.61) | 0.865 | 1.03 (0.66–1.60) | 0.889 |
| Recessive | 140 (97.90) | 522 (98.31) | 0.746 | 1.24 (0.33–4.65) | 0.747 | 1.22 (0.33–4.59) | 0.764 |
|
| |||||||
| rs2273535 T>A (HWE = 0.701) | |||||||
| TT | 66 (46.15) | 234 (44.07) | 1.00 | 1.00 | |||
| TA | 65 (45.45) | 234 (44.07) | 0.82 (0.57–1.16) | 0.263 | 0.82 (0.57–1.17) | 0.265 | |
| AA | 12 (8.39) | 63 (11.86) | 0.56 (0.29–1.08) | 0.084 | 0.56 (0.29–1.08) | 0.085 | |
| Additive | 0.502 | 0.88 (0.67–1.17) | 0.377 | 0.88 (0.67–1.17) | 0.374 | ||
| Dominant | 77 (53.85) | 297 (55.93) | 0.656 | 0.92 (0.63–1.33) | 0.656 | 0.92 (0.63–1.33) | 0.659 |
| Recessive | 131 (91.61) | 468 (88.14) | 0.241 | 0.68 (0.36–1.30) | 0.244 | 0.68 (0.35–1.29) | 0.237 |
|
| |||||||
| rs8173 G>C (HWE = 0.272) | |||||||
| GG | 71 (49.65) | 196 (36.91) | 1.00 | 1.00 | |||
| GC | 54 (37.76) | 263 (49.53) | 0.51 (0.35–0.73) | 0.0003 | 0.50 (0.35–0.73) | 0.0002 | |
| CC | 18 (12.59) | 72 (13.56) | 0.62 (0.35–1.08) | 0.090 | 0.61 (0.35–1.08) | 0.088 | |
| Additive | 0.018 | 0.74 (0.56–0.98) | 0.033 | 0.75 (0.56–0.99) | 0.040 | ||
| Dominant | 72 (50.35) | 335 (63.09) | 0.006 | 0.59 (0.41–0.86) | 0.006 | 0.60 (0.42–0.88) | 0.008 |
| Recessive | 125 (87.41) | 459 (86.44) | 0.762 | 0.92 (0.53–1.60) | 0.762 | 0.92 (0.53–1.61) | 0.781 |
OR, odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium. aχ2 test for genotype distributions between Wilms tumor patients and controls; badjusted for age and gender.