Table 3.
Frequency of inferred haplotypes of the AURKA gene based on observed genotypes and their association with the risk of Wilms tumor.
| Haplotypesa | Cases (n = 286) | Controls (n = 1062) | Crude OR (95% CI) | P | AOR (95% CI)b | P b |
|---|---|---|---|---|---|---|
| CAC | 62 (21.68) | 279 (26.27) | 1.00 | 1.00 | ||
| CAG | 17 (5.94) | 36 (3.39) | 2.00 (1.06–3.77) | 0.033 | 1.99 (1.05–3.77) | 0.034 |
| CTC | 18 (6.29) | 86 (8.10) | 0.89 (0.50–1.57) | 0.676 | 0.91 (0.51–1.62) | 0.748 |
| CTG | 153 (53.50) | 533 (50.19) | 1.21 (0.88–1.68) | 0.240 | 1.21 (0.88–1.67) | 0.249 |
| TAC | 8 (2.80) | 34 (3.20) | 1.00 (0.44–2.25) | 0.990 | 0.99 (0.44–2.24) | 0.983 |
| TAG | 2 (0.70) | 11 (1.04) | 0.77 (0.17–3.55) | 0.736 | 0.74 (0.16–3.40) | 0.694 |
| TTC | 2 (0.70) | 8 (0.75) | 1.06 (0.22–5.09) | 0.945 | 1.09 (0.23–5.28) | 0.913 |
| TTG | 24 (8.39) | 75 (7.06) | 1.35 (0.79–2.30) | 0.266 | 1.34 (0.79–2.29) | 0.279 |
OR, odds ratio; CI, confidence interval; AOR, adjusted odds ratio. aThe haplotype order was rs1047972, rs2273535, and rs8173; bobtained in logistic regression models with adjustment for age and gender.