Table 2.
Muscle Density and Area by Study Arm at Baseline and Difference betweem Week 26 and Baseline
| Muscle measurements | Baseline | P-Value | Difference Week 26 - Baseline |
P value of Difference | ||
|---|---|---|---|---|---|---|
| Tesamorelin (N = 193) | Placebo (N = 148) | Tesamorelin | Placebo | |||
| Anterolateral/abdominal | ||||||
| Muscle density (HU) | 37.3 (10.8) | 35.4 (10.6) | 0.11 | 2.0 (4.9) | −0.6 (4.9) | <0.001 |
| Lean muscle density (HU) | 50.3 (6.2) | 49.3 (5.7) | 0.14 | 0.9 (3.2) | −0.2 (3.4) | 0.002 |
| Muscle area (cm2) | 27.6 (6.2) | 26.0 (6.2) | 0.017 | −0.2 (2.9) | 0 (2.8) | 0.50 |
| Lean muscle area (cm2) | 19.0 (6.3) | 17.2 (6.3) | 0.008 | 0.7 (2.8) | −0.2 (2.7) | 0.003 |
| Rectus | ||||||
| Muscle density (HU) | 32.5 (13.6) | 30.0 (12.8) | 0.089 | 3.5 (7.5) | −0.8 (8.6) | <0.001 |
| Lean muscle density (HU) | 49.2 (8.0) | 47.7 (7.6) | 0.080 | 1.2 (4.5) | −0.2 (5.3) | 0.012 |
| Muscle area (cm2) | 9 (2.5) | 8.2 (2.3) | 0.005 | 0.4 (1.6) | 0.1 (1.2) | 0.055 |
| Lean muscle area (cm2) | 5.8 (2.8) | 5.0 (2.6) | 0.005 | 0.7 (1.6) | −0.1 (1.3) | <0.001 |
| Psoas | ||||||
| Muscle density (HU) | 50.2 (10.3) | 47.6 (9.8) | 0.025 | 0.9 (3.9) | −0.3 (3.4) | 0.004 |
| Lean muscle density (HU) | 57.6 (8.5) | 55.7 (7.9) | 0.033 | 0.2 (3.0) | −0.3 (3.0) | 0.13 |
| Muscle area (cm2) | 18.7 (3.8) | 17.4 (3.7) | 0.002 | 0.4 (1.3) | −0.1 (1.0) | <0.001 |
| Lean muscle area (cm2) | 15.9 (4.0) | 14.6 (3.8) | 0.002 | 0.5 (1.3) | −0.1 (1.0) | <0.001 |
| Paraspinal | ||||||
| Muscle density (HU) | 41.8 (10.9) | 39.8 (10.7) | 0.087 | 1.1 (3.8) | −0.6 (3.4) | <0.001 |
| Lean muscle density (HU) | 54.1 (6.7) | 53.2 (5.8) | 0.17 | 0.3 (2.5) | −0.1 (2.4) | 0.158 |
| Muscle area (cm2) | 25.6 (4.8) | 25.0 (4.8) | 0.26 | 0.2 (1.9) | −0.2 (2.2) | 0.059 |
| Lean muscle area (cm2) | 18.9 (5.9) | 17.8 (6) | 0.12 | 0.5 (2.1) | −0.4 (2.2) | <0.001 |
Abbreviations: HU, Hounsfield units.