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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Reprod Toxicol. 2019 Jul 14;89:83–92. doi: 10.1016/j.reprotox.2019.07.007

Figure 4A and 4B. Correlation matrices of molecular weight and octanol-water partition coefficients (MW and Log Pow); toxicity scores of developmental effects in Caenorhabditis elegans and Danio rerio and mitochondrial membrane potential (MMP) reduction in HepG2 cells; and affinity scores of acetylcholinesterase in humans and rats (hAChE and rAChE), butyrylcholinesterase in humans (hBChE), and mitochondrial translocator proteins in humans and rats (hTSPO and rTSPO) of 32 organophosphates and 18 carbamates.

Figure 4A and 4B.

The affinity scores, toxicity scores, molecular weight, and log Pow of OPs, carbamates were examined with Spearman's rank correlation [44], followed by multiple testing correction with Holm’s method in R version 3.5.1 [33, 45]. The hydrophobicity of organophosphate pesticides was correlated significantly to TSPO binding affinity, MMP reduction, and developmental toxicity in C. elegans and D. rerio. * p < 0.05; ** p < 0.01