Table 3:
OAB Pathway Enrichment Analysis
| # | Pathway | Total Proteins in Pathway | Proteins from Dataset | p-value | FDR p-value |
Affected Proteins from Dataset |
|---|---|---|---|---|---|---|
| 1 | Maturation and migration of dendritic cells in skin sensitization | 41 | 12 | 7.143E-15 | 6.895E-12 | MHC class II beta chain, MHC class II, IL-1 beta, IL-6, IL-8, E-cadherin, CD83, HLA-DRB4, HLA-DRB, TNF-alpha, MHC class II alpha chain, IL-12 beta |
| 2 | NF-kB-, AP-1- and MAPKs-mediated proinflammatory cytokine production by eosinophils in asthma | 43 | 12 | 1.363E-14 | 6.895E-12 | IL-1 beta, IL-6, IL-4, GRO-1, IL-8, GM-CSF, CCL17, MIP-1-alpha, IL-5, ENA-78, TNF-alpha, MGF |
| 3 | PDE4 regulation of cyto/chemokine expression in arthritis | 49 | 12 | 7.771E-14 | 2.621E-11 | IL-1 beta, IL-6, IL-10, IL-8, GM-CSF, MIP-1-alpha, IP10, ENA-78, PKA-reg (cAMP-dependent), TNF-alpha, IL-12 beta, PI3K cat class IA |
| 4 | PDE4 regulation of cyto/chemokine expression in inflammatory skin diseases | 50 | 11 | 3.197E-12 | 8.088E-10 | IL-1 beta, IL-13, IL-6, IL-4, G-protein alpha-i family, IL-10, IL-8, IP10, PKA-reg (cAMP-dependent), TNF-alpha, IL-12 beta |
| 5 | TNF-alpha-induced inflammatory signaling in normal and asthmatic airway epithelium | 38 | 10 | 4.577E-12 | 9.263E-10 | IL-13, IL-6, IL-4, GRO-1, IL-8, GM-CSF, CCL17, IP10, IL-5, TNF-alpha |
| 6 | Inter-cellular relations in COPD (general schema) | 30 | 9 | 1.499E-11 | 2.529E-09 | IL-1 beta, IL-6, GRO-1, Granzyme B, IL-8, GM-CSF, IP10, TNF-alpha, EGF |
| 7 | Proinflammatory cytokine release from eosinophils in asthma | 34 | 9 | 5.305E-11 | 7.669E-09 | IL-1 beta, IL-13, IL-6, NGF, IL-4, IL-8, GM-CSF, IL-5, TNF-alpha |
| 8 | Immune response_T cell subsets: secreted signals | 25 | 8 | 1.185E-10 | 1.498E-08 | IL-13, IL-6, IL-4, IL-10, GM-CSF, MIP-1-alpha, IL-5, TNF-alpha |
| 9 | Proinflammatory cytokine production by Th17 cells in asthma | 53 | 10 | 1.652E-10 | 1.857E-08 | MHC class II, IL-1 beta, IL-13, IL-6, C3aR, IL-4, IL-10, IL-8, IL-5, TNF-alpha |
| 10 | Glomerular injury in Lupus Nephritis | 92 | 12 | 2.085E-10 | 2.110E-08 | IL-1 beta, IL-6, GRO-1, OX40L(TNFSF4), IFI56, IL-8, GM-CSF, GRO-2, MIP-1-alpha, IP10, NGAL, TNF-alpha |
The top 10 enriched molecular pathways that mapped to the dataset of biomarkers associated with OAB. Enriched pathways are identified using MetaCore™. P-value specifies the likelihood that the intersection between the list of affected proteins and a particular network is obtained purely by chance. False discovery rate (FDR)-adjusted p-values are also shown.