Figure 1.
Dynamic susceptibility contrast MRI methods can be leveraged to assess brain tumor hemodynamics in animals (top row), as well as humans (bottom row). Shown are representative post-contrast T1-weighted images (panels a and c) and DSC-MRI derived cerebral blood volume maps (panels b and d) in an orthotopic C6 rodent glioma model and a patient with a high-grade glioma. Post-contrast T1-weighted images are routinely used to visualize the primary tumor mass due to the accumulation of contrast agent in regions with a disrupted blood brain barrier. In animals and humans, high grade gliomas exhibit CBV values that are markedly higher than that found in normal appearing white matter.