Table 2.
Univariate and multivariate analyses for risk factors associated with NIV failure in the derivation cohort
| Univariate analyses OR (95% CI) |
p | Multivariate analyses OR (95% CI) |
p | |
|---|---|---|---|---|
| Chronic kidney disease | 2.219 (1.147–4.292) | 0.02 | – | – |
| APACHE II score | 1.208 (1.150–1.270) | < 0.01 | – | – |
| Data collected before NIV | ||||
| Heart rate, beats/min | 1.025 (1.014–1.037) | < 0.01 | – | – |
| pH | 0.004 (0.000–0.084) | < 0.01 | – | – |
| PaO2/FiO2, mmHg | 0.996 (0.993–0.999) | 0.01 | – | – |
| GCS | 0.651 (0.558–0.759) | < 0.01 | – | – |
| Data collected at 1–2 h of NIV | ||||
| Respiratory rate, breaths/min | 1.122 (1.076–1.170) | < 0.01 | 1.064 (1.001–1.131) | 0.05 |
| Heart rate, beats/min | 1.035 (1.024–1.047) | < 0.01 | 1.027 (1.011–1.043) | < 0.01 |
| Systolic blood pressure, mmHg | 1.015 (1.005–1.024) | < 0.01 | – | – |
| Diastolic blood pressure, mmHg | 1.027 (1.011–1.044) | < 0.01 | – | – |
| pH | 0.000 (0.000–0.000) | < 0.01 | 0.000 (0.000–0.000) | < 0.01 |
| PaCO2, mmHg | 1.037 (1.024–1.051) | < 0.01 | – | – |
| PaO2/FiO2, mmHg | 0.991 (0.987–0.994) | < 0.01 | 0.995 (0.990–0.999) | 0.02 |
| GCS | 0.331 (0.245–0.447) | < 0.01 | 0.371 (0.269–0.512) | < 0.01 |
NIV noninvasive ventilation, OR odds ratio, CI confidence interval, GCS Glasgow coma scale