Table 1.

Trace mineral concentrations in test and control population dogs

	Mineral concentrations (μg/g)
Mineral (RI)	Control liver	Test liver	Test HCC
Zinc (75‐225 μg/g)	151.5†	132.1*, †	93.8*
	(117.1‐184.5)	(108.6‐163.2)	(72.2‐134.3)
Selenium (1.5‐4.3 μg/g)	2.1	2.0*	1.3*
	(1.8‐2.5)	(1.6‐2.4)	(1.1‐1.7)
Iron (500‐4150 μg/g)	1691	1716*	947*
	(1019‐2441)	(1003‐2473)	(563‐1463)

Note: Values represent the median concentrations (μg/g) for each mineral, and the IQR is provided in parentheses. Control liver, hepatic tissue from the control population dogs; Test liver, non‐neoplastic hepatic tissue from the test population dogs; Test HCC, neoplastic tissue from test population dogs.

Abbreviation: HCC, hepatocellular carcinoma; RI, reference interval.

^* P < .001.

^† P = .03.