Table 1.

PK parameters of MPA in plasma from cats following oral administration of MMF at 10 mg/kg every 12 hours and 15 mg/kg every 12 hours and every 8 hours for up to 7 days

Dose		Individual
10 mg/kg	Pharmacokinetic parameter	Cat 1	Cat 2		Cat 3	Mean
After first dose (n = 3)	Time to maximum concentration (h)	0.5	1.5		0.5	0.5
	Observed maximum concentration (μg/mL)	0.35	0.55		1.3	0.73
	Concentration at 12‐h post‐MMF administration (μg/mL)	BLLOQ	BLLOQ		BLLOQ	NA
	AUC0–loq (h·μg/mL)	2.03	1.28		1.35	1.55
After last dose (n = 3)	Time to maximum (h)	0.5	0.5		0.5	0.5
	Observed maximum concentration (μg/mL)	1.23	3.78		1.88	2.29
	Concentration at 12‐h post MMF administration (μg /mL)	BLLOQ	BLLOQ		0.34	NA
	AUC0–loq (h·μg /mL)	1.77	8.54		4.56	4.95
15 mg/kg q12h	Pharmacokinetic parameter	Cat 4	Cat 5		Cat 6	Mean
After first dose (n = 3)	Time to maximum (h)	1	1		1	1
	Observed maximum concentration (μg/mL)	2.24	4.11		3.24	3.19
	Concentration at 12‐h post‐MMF administration (μg /mL)	BLLOQ	BLLOQ		0.51	NA
	AUC0–loq (h·μg/mL)	2.15	5.37		5.47	4.33
After last dose (n = 2)	Time to maximum (h)	0.25	NA		0.25	0.25
	Observed maximum concentration (μg/mL)	4.84	NA		3.01	3.92
	Concentration at 12‐h post MMF administration (μg /mL)	BLLOQ	NA		BLLOQ	NA
	AUC0–loq (h·μg /mL)	2.52	NA		6.03	4.27
15 mg/kg q8h	Pharmacokinetic parameter	Cat 7	Cat 8	Cat 9	Cat 10	Mean
After first dose (n = 4)	Time to maximum (h)	0.25	0.5	1.5	1.5	0.93
	Observed maximum concentration (μg/mL)	3.0	6.63	0.86	1.40	2.97
	Concentration at 12‐h post MMF administration (μg /mL)	0.59	1.36	0.70	0.60	0.81
	AUC0–loq (h·μg /mL)	14.9	31.0	5.57	9.48	15.2

Abbreviations: BLLOQ, below lower limit of quantification (0.3 μg/mL); NA, not applicable.

For 10 mg/kg dosage regimen protocol, the median observed maximum plasma concentration and AUC_0‐loq after the first and last dose were not different (P = .2).