Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 24;13:3391–3404. doi: 10.2147/DDDT.S222296

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Wang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Mitigative effects of paclitaxel on lung injury induced by CLP were reversed by MUC1 inhibitor. Different doses of GO203 (specific inhibitor MUC1) (10, 20, 30 mg/kg) and its negative control CP2 (10, 20, 30 mg/kg) were injected intraperitoneally in mice prior to CLP and paclitaxel treatment. (A–C) TLR 4 and p-NF-κB/p65 were detected by Western blot. (D–G) Representative morphological images at 24 hrs by HE staining were presented to assess the injury severity of lungs, heart, kidney and liver. (H–K) Histological scores of organ injury were calculated. Samples were harvested at 24 hrs after CLP. Data represent means ± SD (n=6). *P<0.05, **P<0.01, ***P<0.001.