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. 2019 Sep 24;13:3391–3404. doi: 10.2147/DDDT.S222296

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© 2019 Wang et al.

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Mitigative effects of paclitaxel in LPS-stimulated A549 cells were reversed by MUC1 knock-down. (A–D) A549 cells were transfected with NC-siRNA or MUC1-siRNAs for 24 hrs. Expression levels of TLR 4, p-NF-κB/p65 and MUC1 were detected by Western blot. (E–H) A549 cells transfected with NC-siRNA or MUC1-siRNAs for 24 hrs were treated with LPS (2.5 μg/mL) and paclitaxel (5 nM) for another 24 hrs. Expression levels of TLR 4, p-NF-κB/p65 and MUC1 were detected by Western blot. (I) The levels of IL-1β, IL-6, TNF-α, IL-10 in the culture supernatants were analyzed by ELISA. Data represent mean ± SD (n=6). *P<0.05, **P<0.01, ***P<0.001.