Figure 1.
Experiment flowchart. Part 1: Rats were subjected to acute myocardial infarction (AMI) model procedure, followed by high dose of intensive atorvastatin (ATV, 10 mg/kg per day) intragastrically until different endpoints of 1 day (d1), 1 week (d7), 2 weeks (d14), 3 weeks (d21), and 4 weeks (d28) post‐AMI. Part 2: Rats were subjected to AMI model procedure, followed by intensive ATV intragastrically for 6 weeks. Cell delivery in nine transplantation groups was conducted according to the time point on the schematic. 2 × 106 CM‐Dil labeled ATV pretreated‐MSCs were transplanted through vein tail in each injection. Baseline and endpoint echocardiography were assessed on 3 days and 6 weeks post‐AMI, respectively. Abbreviation: SD rats, Sprague–Dawley rats.