Table 2.

Fasting blood parameters from experimental protocol 1

Fasting Blood Parameter	Wild-Type Chow	eET-1 Chow	Wild-Type WD	eET-1 WD	ANOVA
Cholesterol, mg/dL	43.4 ± 2.1	44.5 ± 1.9	101.0 ± 7.3	93.1 ± 6.8	G × D: NS G: NS D: P < 0.05
Triglycerides, mg/dL	124.5 ± 4.7	140.5 ± 9.4	121.4 ± 5.4	133.8 ± 7.5	G × D: NS G: NS D: NS
HDL, mg/dL	23.8 ± 1.0	24.6 ± 1.0	40.9 ± 1.8	37.1 ± 1.8	G × D: NS G: NS D: P < 0.05
LDL, mg/dL	4.0 ± 0.3	4.1 ± 0.3	8.5 ± 0.6	7.6 ± 0.9	G × D: NS G: NS D: P < 0.05
NEFA, mmol/L	0.40 ± 0.03	0.30 ± 0.05	0.29 ± 0.03	0.28 ± 0.05	G × D: NS G: NS D: NS
Insulin, g/dL	0.52 ± 0.04	0.44 ± 0.04	1.68 ± 0.13	1.67 ± 0.26	G × D: NS G: NS D: P < 0.05
Glucose, mg/dL	206.6 ± 8.0	178.0 ± 11.9	269.3 ± 14.8	225.3 ± 25.7	G × D: NS G: NS D: P < 0.05

Values are means ± SE. Bold values indicate statistical significance. D, main effect of diet; eET-1, endothelial cell-specific human prepro-endothelin-1; G, main effect of genotype; G × D; genotype × diet interaction; NEFA, nonesterified fatty acid; NS, nonsignificant (P > 0.05); WD, Western diet.