A: effect of rimonabant (RIM) on uncoupling protein 1 (UCP1) gene expression in the subcutaneous (SC) and visceral (VIS) adipose tissue with representative immunohistochemistry images of UCP1 protein in the SC and VIS adipose tissue. B: sarcoendoplasmic reticulum calcium ATPase 2b (SERCA2b), ryanodine receptor 2 (RyR2), glucose transporter4 (Glut4), and hexokinase 2 gene expressions. Placebo (PL), n = 9; RIM, n = 11. P values vs. pre-fat period (*P < 0.05) and vs. high-fat diet (HFD) (#P < 0.05). Data are means ± SE.