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. 2019 Jun 19;317(3):C492–C501. doi: 10.1152/ajpcell.00058.2019

Fig. 4.

Fig. 4.

Effect of aryl hydrocarbon receptor nuclear translocator-like protein-1 (BMAL1) on mRNA expression levels of paired-homeodomain transcription factor 4 (PAX4) and different transcription factors. Differentiated Caco-2 cells were transduced with control shRNA (shControl) or BMAL1 shRNA (shBMAL1) (A) or adenovirus (Adv)-Control or Adv-BMAL1 (B) for 72 h and then used to quantify mRNA levels of PAX4 and different transcription factors. Each bar represents the mean ± SE of 3 separate trials. CDX2, caudal-type homeobox protein-2; DBP, D-box-binding proline- and acid-rich basic region leucine zipper (PAR bZIP) transcription factor; FOXA2 and FOXO1, forkhead box proteins A2 and O1, respectively; GATA4 and GATA6, GATA-binding proteins-4 and -6, respectively; HNF1α and HNF1β, hepatocyte nuclear factors 1-α and 1-β, respectively; SHP, small heterodimer partner; SP1, Sp1 transcription factor. *P < 0.05, ***P < 0.001, significantly different from each Control.