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. 2019 Jul 3;317(3):C481–C491. doi: 10.1152/ajpcell.00150.2019

Fig. 6.

Fig. 6.

Effects of different sphingolipids on transient receptor potential mucolipin 1 (TRPML1) channel currents. A: representative images of 1) differential interference contrast (DIC) picture of suspended podocyte, 2) DIC picture of the isolated lysosome, and 3) isolated lysosome stained with LysoTracker. B: the purity of isolated lysosomes detected by flow cytometry (n = 5). C: representative whole lysosome currents enhanced by ML-SA1. D: ML-SA1 enhanced TRPML1 channel activity in a concentration-dependent manner (n = 5). E: summarized data of the effects of various sphingolipids on whole lysosome currents (n = 5). *P < 0.05 vs. unstained lysosomes, control (Ctrl), or vehicle (Vehl)-Ctrl. #P < 0.05 vs. Vehl-ML-SA1. SM, sphingomyelin; Cer, ceramide; Sph, sphingosine.