Fig. 1.

Loss of CD73 on pericytes/fibroblasts prevents recovery of kidney function after ischemia-reperfusion injury (IRI). Unilateral IRI was performed on kidneys from Foxd1Cre CD73^fl/fl (n = 9) and littermate control (Con; n = 9) mice, and plasma creatinine (PCr; A) as well as kidney transcript levels of kidney injury molecule-1 (Kim1; B, left) and neutrophil gelatinase-associated lipocalin (Ngal; B, right) relative to Gapdh (relative mRNA levels, fold changes) were measured 24 h later. In a separate group of mice, unilateral IRI was performed on kidneys from Foxd1Cre CD73^fl/fl (n = 9) and littermate Con (n = 10) mice, a nephrectomy of the contralateral Con kidney was performed on day 13, and PCr was measured on day 14 (C). ***P < 0.001 by and unpaired t-test.