TABLE 3.

Genetic variants in the NOTUM locus are associated with BMD

SNP	Chr	Position	A1	A2	AF	β	SE	P	N
rs35344256	17	79934194	C	A	0.69	−0.0134	0.0020	1.5E−11	445921
rs147901986	17	79921522	G	A	0.97	0.0386	0.0059	4.6E−11	445921

Large-scale human genetic analyses revealed that genetic variants in the NOTUM locus are associated with BMD. We specifically searched for possible associations between imputed SNPs (minor allele frequency >1%) in the NOTUM locus ±25 kb (in total 125 SNPs with a minor allele frequency >1% were evaluated) and BMD as estimated by quantitative ultrasound of the heel. A1, effect allele; A2, other allele; AF, allele frequency of allele 1. Independent SNPs associated with BMD and with P < 1 × 10⁻¹⁰. β given as sd change in eBMD per effect allele.