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. 2019 Jul 12;33(10):10872–10888. doi: 10.1096/fj.201900767R

Figure 5.

Figure 5

Tg.Sirt6 mice are protected from developing diabetic cardiomyopathy. N.Tg controls and Tg.Sirt6 mice were fed an HF-HS diet for 24 wk. A) Age-dependent body weight gain in N.Tg and Tg.Sirt6 mice. B) Weight gain of Tg.sirt6 mice fed either a normal diet (ND) or HF-HS diet. C) Mice were fed a ND or HF-HS diet for 24 wk, and their heart weight/tibia length (HW/TL) ratio, a marker of hypertrophy, was measured. Values are means ± se; n = 7. D) Heart sections were stained with Masson’s trichrome (blue) to visualize interstitial myocardial fibrosis. Scale bars, 20 μM. E) Quantitation of myocardial fibrosis in different groups of mice. Values are means ± se; n = 5.