Figure 7.
Heart mitochondria of Tg.Sirt6 mice are preserved post–HF-HS feeding. A) Electron micrographs showing mitochondrial damage and lipid accumulation (arrow) in the hearts of WT controls but not in Tg.Sirt6 mice fed a HF-HS diet for 24 wk. Scale bars, 1 µM. B) Western blot analysis of the heart lysate showing preservation of proteins regulating mitochondrial fusion and down-regulation of fission proteins in HF-HS–fed Tg.Sirt6 mice. C) Enzymatic activity of citrate synthase in the hearts of different groups of mice. Values are means ± se; n = 5.