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. 2019 Jul 10;33(10):11096–11108. doi: 10.1096/fj.201802663R

Figure 1.

Figure 1

Drp1 siRNA attenuated Dox-induced mitochondrial fragmentation. H9c2 cells were cultured, infected with AdDsRed, transfected with siDRP1 or control siRNA (siCon), and then exposed to either Dox (750 nM) or saline for 24 h. Mitochondrial morphology was analyzed using ImageJ and the following parameters were calculated: mitochondrial particle number and size, mean FF, and AR. At least 5 images (each containing 5–15 cells) were captured per treatment over 3 separate experiments. Data are expressed as means ± se and were analyzed by ANOVA. *P < 0.01 vs. control (n = 3–4).