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DRP1 haploinsufficiency blocked Dox-induced release of LDH and cTnI into the bloodstream. The DRP1 heterozygous knockout mice (DRP1+/−) were treated for 3 d with saline or Dox (15 mg/kg body weight). The serum LDH activity (A) and the serum levels of cTnI (B) were determined by using commercial kits. Data are expressed as means ± se and were analyzed by 1-way ANOVA. *P < 0.01 vs. wild-type control, #P < 0.01 vs. Dox-treated wild type (n = 8–12).
