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. 2019 Jul 10;33(10):11096–11108. doi: 10.1096/fj.201802663R

Figure 7.

Figure 7

DRP1 haploinsufficiency attenuated Dox-induced oxidative injuries in the mouse heart. The DRP1+/− mice were treated with saline or Dox (15 mg/kg body weight). Mice were euthanized 3 d later, and cardiac tissues were processed for Western blot analysis of cCasp3 (A), oxidized protein (B; Oxyblot), lipid peroxidation by-product 4-HNE (C), and phospho-PDH (D). Data are expressed as means ± se and were analyzed by 1-way ANOVA. *P < 0.01 vs. wild-type control, #P < 0.01 vs. Dox-treated wild-type (n = 6).