Figure 3.

(E)-2-dodecenal is the KCNQ2/3-activating metabolite in cilantro All error bars indicate sem. Red box indicates the sole hit, (E)-2-dodecenal. A) Chemical structures (left; red indicates oxygen) and electrostatic surface plots (right; red, negative; blue, positive) of the cilantro compounds screened in this study. B) Mean TEVC current traces showing effects of compounds in A (all 100 µM) on KCNQ2/3 expressed in Xenopus oocytes (n = 5–11). C) Mean tail current (left) and normalized tail currents (G/G_max) (right) vs. prepulse voltage relationships for the traces as in B (n = 5–11). 3,4-DHBA, 3,4-dihydroxybenzoic acid.