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Schematic representation of the pathways that mediate the effects of NANOG on COL3 expression by senescent cells. NANOG restored COL3 expression by reactivating the TGF-β pathway through transcriptional control of several genes in that pathway. Also, NANOG directly bound to SMAD2/3 promoter and phosphorylated protein, which might further activate the TGF-β pathway and contribute to restoration of COL3 expression.
