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. 2019 Jul 10;33(10):11210–11222. doi: 10.1096/fj.201900797R

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© The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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IGF-1 is elevated in the PF of women with endometriosis, and concentrations positively correlate with pain score. A) ELISA analysis of PF from patients with endometriosis (n = 13; ENDO) revealed an increase (P < 0.05) in protein concentrations of IGF-1 compared with patients without endometriosis (n = 9; No Endo). B) We detected a positive correlation between patient self-reported pain score [in women with chronic pelvic pain and endometriosis (pink dots) and chronic pelvic with no obvious pathology (blue dots)] and IGF-1 protein concentrations. Statistical analysis was performed using a Student’s t test or Pearson’s r test for correlation. *P < 0.05.