Fig. 2.

Histone deacetylase (HDAC) activity in skeletal muscle of SIV-infected macaques. A: there was a main effect of chronic binge alcohol (CBA) and antiretroviral therapy (ART) to significantly increase total nuclear HDAC activity in skeletal muscle. Control (white bars); sucrose (VEH)/simian immunodeficiency virus (SIV)/ART− (light gray bars), VEH/SIV/ART+ (light gray diagonally hatched bars), CBA/ SIV/ ART− (dark gray bars) and CBA/SIV/ART+ (dark gray diagonally hatched bars). B: there was a significant positive correlation of HDAC4 expression with total nuclear HDAC activity. RFU, relative fluorescence units. 2-way ANOVA and Pearson correlation. Values are means ± SE.