Fig. 9.

Venn diagram-based representation of differentially regulated hepatic miRNAs in response to diet-induced hyperglycemia in glucose-intolerant rainbow trout (current study), glucose-tolerant blunt snout bream (47) and rodent models of diet-induced hyperglycemia (26, 27, 36, 82). The identification of common differentially regulated hepatic miRNAs in hyperglycemic conditions between these species is indicated in intersections of the Venn diagram. Differentially regulated miRNAs in response to hyperglycemic conditions identified in rainbow trout, blunt snout bream, and mammalian models are indicated in the center of the Venn diagram. The directional change of specific miRNA expression within specific studies is indicated as follows: For each individual miRNA, an arrow to its left indicates the observed miRNA expression change observed in rainbow trout in the current study, an arrow to its right the observed expression changes in the glucose-tolerant blunt snout bream and an arrow located below each specific miRNA indicates its expression change observed in mammalian studies.