Fig. 4.

Baseline (open circles) and post-sleep deprivation (post-SD) (closed circles) time in nonrapid eye movement sleep (NREMS) and rapid eye movement sleep (REMS) for wild-type (WT), brain-specific interleukin-1 receptor accessory protein (AcPb) knockout (KO), and AcP KO mice for the first 24 h post-SD. SDs occurred between zeitgeber time (ZT)20–ZT4 (top) and ZT8–ZT16 (bottom), expressed as a percent of total minutes in each 2-h bin. Each data point is a 2-h average ± SE. Time in the ZT4–ZT6 bin is a percent of 102 min due to the loss of the first 18 min of recovery for 9 AcP KO subjects from the ZT20–ZT4 SD. Gray background indicates lights off. *P < 0.05 and **P < 0.01, baseline vs. post-SD.