Fig. 5.

Influence of swine coronary adipose conditioned medium on mouse aortic oxidative stress and inflammation. Nitrotyrosine (NT; A) and NF-κB p65 (B) were unchanged after culture in coronary adipose conditioned medium, but the advanced glycation end product inhibitor aminoguanidine (AMG) decreased NT and NF-κB p65 level in all groups (n = 6/group): control (CON), heart failure (HF), HF continuous exercise trained (HF+CONT), and HF interval exercise trained (HF+IT). AU, arbitrary units. Data are means ± SE. ^$−AMG vs. +AMG within group, P < 0.05. Data were analyzed with a 2-way ANOVA. Right: representative immunohistochemistry images of mouse aorta showing NT and NF-κB p65 level. Scale bars, 100 μm.