Table 1.

Biochemical profile

Parameter	Control	DAAO	Sac/Val	Val	Normal Range (Reference)
n	3	6	6	5
Sodium, mEq/L	191.8 ± 4.4	164.5 ± 4.4	177.7 ± 5.9	176.0 ± 9.9	141–149 (8a)
Potassium, mEq/L	4.8 ± 0.5	5.2 ± 0.3	5.3 ± 0.3	5.2 ± 0.3	5.2–7.8 (8a)
Chloride, mEq/L	144.8 ± 5.5	118.0 ± 4.0	132.7 ± 5.4	131.3 ± 10.6	102–109 (8a)
ALT, U/L	68.3 ± 11.5	60.3 ± 9.6	58.3 ± 7.4	96.8 ± 25.8	20–42 (8a)
AST, U/L	97.0 ± 18.2	165.2 ± 41.3	128.2 ± 30.9	223.6 ± 91.5	39–84 (8a)
Creatinine, mg/dL	0.3 ± 0.0	0.2 ± 0.0	0.5 ± 0.1**	0.3 ± 0.0	0.3–0.5 (4)
BUN, mg/dL	35.0 ± 3.0	34.3 ± 2.3	49.7 ± 3.7*	43.4 ± 4.9	16–23 (8a)

Values are means ± SE; n = no. of rats. Serum chemistry values of control (n = 3), d-amino acid oxidase (DAAO)-expressing rats (n = 6), and DAAO-expressing rats then treated with sacubitril/valsartan (Sac/Val; n = 6) or valsartan (Val; n = 5). ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen.

^*P < 0.05,

^**P < 0.01 for sacubitril/valsartan vs. DAAO, obtained by 1-way ANOVA with Šídák’s multiple-comparison test or Kruskal-Wallis test followed by Dunn’s multiple-comparison test.