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Deficiency of Crb3 in DLD‐1 inhibits liver metastasis in vivo. (a) Crb3 deficiency was examined in DLD‐1 xenograft in NOD/SCID mice. Suspension of wt or Crb3‐KO DLD‐1 cells were intrasplenically injected. (b) Immunohistochemistry of metastatic foci in the liver from wt DLD‐1 cell injected mice. Thin lined hatched boxes indicate liver metastatic lesions formed in wt DLD‐1 injected mice.
