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. 2019 Sep 17;24(18):3379. doi: 10.3390/molecules24183379

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lipoprotein lipase is a target of miR-152. (A) The sequence alignment of miR-152 with 3′-UTR of mouse lipoprotein lipase (LPL) mRNA. The binding site and seed region of miR-152 re indicated in bold. (B) The minimum free energy of miR-152 and LPL mRNA was predicted using RNAhybrid. (C) The mRNA expression level of LPL was detected by qRT-PCR after 3T3-L1 cells transfected with the miR-152 mimic, the miR-152 inhibitor or the negative control on day eight. (D) The repressive effect of miR-152 on the activity of LPL 3′UTR was measured by a dual-luciferase assay. Results are presented as means ± SD. n = 3. * p < 0.05; ** p < 0.01.